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Related Concept Videos

Degenerative Disc Disease I: Introduction01:27

Degenerative Disc Disease I: Introduction

Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
Herniated Intervertebral Disc l: Introduction01:29

Herniated Intervertebral Disc l: Introduction

Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...

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Updated: Jun 23, 2026

Biomechanical Changes Related to Low Back Pain: An Innovative Tool for Movement Pattern Assessment and Treatment Evaluation in Rehabilitation
06:28

Biomechanical Changes Related to Low Back Pain: An Innovative Tool for Movement Pattern Assessment and Treatment Evaluation in Rehabilitation

Published on: December 13, 2024

[A 61-year-old man with sciatica].

Kristin Lif Breivik1, Ricardo Laurini, Rolf Steen

  • 1Nevrologisk avdeling, Sentralsjukehuset i Sogn og Fjordane, 6807 Førde. kristin.lif.breivik@helse-forde.no

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|May 19, 2009
PubMed
Summary
This summary is machine-generated.

A man with neurological symptoms including gait difficulties and paralysis was diagnosed posthumously with lung cancer that had spread to the meninges. This case highlights meningeal carcinomatosis as a rare but fatal complication of lung adenocarcinoma.

Related Experiment Videos

Last Updated: Jun 23, 2026

Biomechanical Changes Related to Low Back Pain: An Innovative Tool for Movement Pattern Assessment and Treatment Evaluation in Rehabilitation
06:28

Biomechanical Changes Related to Low Back Pain: An Innovative Tool for Movement Pattern Assessment and Treatment Evaluation in Rehabilitation

Published on: December 13, 2024

Area of Science:

  • Neurology
  • Oncology
  • Pathology

Background:

  • Neurological deterioration can be caused by various conditions, including neoplastic spread.
  • Meningeal carcinomatosis is a rare complication of solid tumors, particularly lung cancer.

Observation:

  • A 61-year-old man presented with progressive neurological deficits, including paraparesis, cranial nerve palsies, and cognitive decline.
  • Initial investigations including MRI and malignancy screening were inconclusive.
  • Cerebrospinal fluid analysis revealed low glucose, mild pleocytosis, and elevated protein.

Findings:

  • Autopsy identified a primary lung adenocarcinoma.
  • The autopsy also revealed meningeal carcinomatosis, indicating leptomeningeal metastasis from the lung cancer.

Implications:

  • This case underscores the importance of considering meningeal carcinomatosis in patients with unexplained neurological decline, even with negative initial workups.
  • Early diagnosis and management of leptomeningeal metastasis are crucial for improving patient outcomes in lung cancer.
  • Autopsy remains vital for establishing definitive diagnoses in complex neurological cases.