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Danshen extracts decrease blood C reactive protein and prevent ischemic stroke recurrence: a controlled pilot study.

Gelin Xu¹, Wenxin Zhao, Zhiming Zhou

¹Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu Province, China. gelinxu@gmail.com

Phytotherapy Research : PTR

|May 19, 2009

Summary

This summary is machine-generated.

Danshen dripping pill (DDP), a herbal formula, significantly reduced recurrent stroke and transient ischemic attack (TIA) risk in patients. This may be linked to DDP's anti-inflammatory effects.

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Area of Science:

Cardiovascular Medicine
Neurology
Integrative Medicine

Background:

Ischemic cerebrovascular disease poses a significant risk for recurrent stroke and transient ischemic attack (TIA).
Secondary stroke prevention strategies are crucial for managing patients with a history of ischemic events.
Herbal preparations are increasingly explored for their therapeutic potential in cardiovascular health.

Purpose of the Study:

To evaluate the efficacy of Danshen dripping pill (DDP) in secondary prevention of stroke and TIA.
To assess the impact of DDP on cerebrovascular event recurrence, mortality, and hematological parameters.
To investigate the potential anti-inflammatory mechanisms of DDP in patients with ischemic cerebrovascular disease.

Main Methods:

A prospective study involving 106 patients with recent ischemic stroke or TIA.
Patients were divided into two groups: one receiving DDP (Salvia miltiorrhiza, Panax notoginseng, Dryobalanops camphor) and a control group.
Outcomes including recurrent stroke/TIA, mortality, adverse events, and blood markers were monitored over a 1-year follow-up.

Main Results:

DDP group showed a significantly lower rate of recurrent stroke/TIA (9.6%) compared to the control group (24.1%) (p<0.05).
No significant differences in mortality or intracranial hemorrhage were observed between the groups.
Blood C-reactive protein levels decreased significantly in the DDP group, suggesting an anti-inflammatory effect.

Conclusions:

Danshen dripping pill (DDP) demonstrates potential in reducing the risk of recurrent stroke and TIA in patients with ischemic cerebrovascular disease.
The anti-inflammatory properties of DDP may contribute to its efficacy in secondary stroke prevention.
Further research is warranted to elucidate the precise mechanisms and long-term benefits of DDP in cerebrovascular disease management.