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[Clonidine and postoperative shivering].

C Launo1, S Palermo, M R Germi

  • 1Istituto di Anestesiologia e Rianimazione, Università degli Studi di Genova.

Minerva Anestesiologica
|July 1, 1991
PubMed
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Methylphenidate is the top choice for treating postoperative shivering. Clonidine (75 micrograms) effectively suppresses shivering without causing significant changes in patient hemodynamics or temperature.

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Critical Care Medicine

Background:

  • Postoperative shivering is a common complication following anesthesia.
  • Existing treatments for shivering may have associated hemodynamic or temperature side effects.
  • Novel therapeutic strategies are needed to manage postoperative shivering effectively and safely.

Purpose of the Study:

  • To evaluate the efficacy of clonidine in suppressing postoperative shivering.
  • To compare different doses of clonidine (75 and 150 micrograms) against methylphenidate and saline placebo.
  • To assess the impact of clonidine on patient hemodynamics and temperature post-surgery.

Main Methods:

  • A double-blind clinical trial involving 60 patients undergoing general, thoracic, or vascular surgery.

Related Experiment Videos

  • Patients received either clonidine (75 mcg or 150 mcg), methylphenidate, or a saline placebo.
  • Shivering inhibition was measured using the Goldfarb scale; hemodynamic and temperature parameters were monitored.

    • Main Results:

    • Methylphenidate was identified as the primary drug of choice for postoperative shivering.
    • Clonidine at a 75 microgram dose demonstrated significant inhibition of postoperative shivering.
    • The 75 microgram dose of clonidine did not result in notable hemodynamic or temperature variations.

    Conclusions:

    • Methylphenidate is recommended as the first-line treatment for postoperative shivering.
    • Low-dose clonidine (75 micrograms) offers a viable alternative for shivering suppression.
    • Clonidine, at 75 mcg, provides effective shivering control without adverse hemodynamic or thermoregulatory effects.