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Related Concept Videos

Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Angina IV: Management01:26

Angina IV: Management

IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...

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Related Experiment Videos

Diabetes: managing dyslipidaemia.

Jigisha Patel1

  • 1Royal Free and UCL Medical School, Division of Medicine, Centre for Clinical Science and Technology, University College London, London, UK.

BMJ Clinical Evidence
|May 20, 2009
PubMed
Summary

This systematic review examines interventions for dyslipidaemia in people with type 2 diabetes. It found various treatments, including statins and fibrates, to be effective in managing lipid levels and reducing cardiovascular risk.

Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Background:

  • Dyslipidaemia significantly increases heart disease risk in diabetic patients, with elevated LDL-C correlating to higher coronary heart disease (CHD) risk.
  • Diagnosis and pharmacological treatment for diabetic dyslipidaemia depend on lipid profiles and overall cardiovascular risk assessment.

Purpose of the Study:

  • To systematically review the effects of various interventions on dyslipidaemia in individuals with diabetes.
  • To evaluate the effectiveness and safety of lipid-modifying treatments for diabetic dyslipidaemia.

Main Methods:

  • A systematic review was conducted, searching major medical databases (Medline, Embase, Cochrane Library) up to June 2007.
  • Included studies comprised systematic reviews, randomized controlled trials (RCTs), and observational studies, with a GRADE evaluation of evidence quality.

Related Experiment Videos

  • Harms alerts from regulatory agencies (FDA, MHRA) were also incorporated.

    • Main Results:

    • Twenty-one studies met the inclusion criteria for the systematic review.
    • The review assessed the quality of evidence for different interventions using the GRADE system.

    Conclusions:

    • The review presents data on the effectiveness and safety of multiple interventions for diabetic dyslipidaemia.
    • Interventions evaluated include anion exchange resins, combined treatments, ezetimibe, fibrates, fish oil, intensive multi-intervention programs, nicotinic acid, and statins.