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Related Experiment Video

Updated: Jun 23, 2026

A Mouse Model of Ankle-Subtalar Complex Joint Instability

A Mouse Model of Ankle-Subtalar Complex Joint Instability

Published on: October 28, 2022

Ankle sprain.

Peter Struijs¹, Gino Kerkhoffs

¹Resident surgery, Ferik Hendrikplontsoen 74-2, Amsterdam, Netherlands.

BMJ Clinical Evidence

|May 20, 2009

Summary

This summary is machine-generated.

This systematic review examines treatments for acute ankle ligament ruptures, common in sports injuries. It evaluates interventions like physiotherapy and surgery to determine effectiveness and safety.

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Area of Science:

Orthopedics
Sports Medicine
Evidence-Based Medicine

Background:

Ankle ligament injuries affect approximately 1 in 10,000 individuals daily.
These injuries constitute a significant portion, about 25%, of all sports-related injuries.

Purpose of the Study:

To systematically review and synthesize evidence on treatment strategies for acute ankle ligament ruptures.
To assess the effectiveness and safety of various interventions for ankle ligament injuries.

Main Methods:

Conducted a systematic literature review up to March 2007.
Searched major databases including Medline, Embase, and The Cochrane Library.
Included harms alerts from regulatory agencies like the FDA and MHRA.

Main Results:

Included 35 systematic reviews, randomized controlled trials (RCTs), and observational studies.
Performed a GRADE evaluation to assess the quality of evidence for different interventions.

Conclusions:

Presents findings on the effectiveness and safety of interventions for acute ankle ligament ruptures.
Evaluated treatments such as cold therapy, diathermy, functional treatment, homeopathic ointments, immobilization, physiotherapy, surgery, and ultrasound.