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Acne Infection

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...

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Candidiasis

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A Rat Model of Compound Acne

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Acne vulgaris.

Sarah Purdy¹, David Deberker

¹University of Bristol, Bristol, UK.

BMJ Clinical Evidence

|May 20, 2009

Summary

This summary is machine-generated.

This systematic review evaluates topical and oral treatments for acne vulgaris, common in teenagers and adults. It summarizes evidence on the effectiveness and safety of various interventions for managing acne lesions.

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Area of Science:

Dermatology
Pharmacology
Evidence-based Medicine

Background:

Acne vulgaris is highly prevalent, affecting over 80% of adolescents and persisting into adulthood for a significant percentage of men and women.
Acne lesions range from comedones and inflammatory papules to severe nodules and cysts, which can lead to scarring and psychological distress.

Purpose of the Study:

To systematically review and synthesize the evidence on the efficacy and safety of topical and oral treatments for acne vulgaris.
To answer the clinical question regarding the effects of various interventions in individuals with acne.

Main Methods:

A systematic literature search was conducted across major databases (Medline, Embase, Cochrane Library) up to June 2007.
Included studies comprised systematic reviews, randomized controlled trials (RCTs), and observational studies.
Harms alerts from regulatory agencies like the FDA and MHRA were also incorporated.

Main Results:

A total of 67 studies met the inclusion criteria for the review.
The quality of evidence for different interventions was assessed using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system.

Conclusions:

The review presents findings on the effectiveness and safety of numerous topical acne treatments, including adapalene, azelaic acid, benzoyl peroxide, clindamycin, erythromycin, isotretinoin, tetracycline, and tretinoin.
Information on oral treatments such as doxycycline, isotretinoin, lymecycline, minocycline, oxytetracycline, and tetracycline is also provided.