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Updated: Jun 23, 2026
06:53
Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
Basal cell carcinoma.
Sanjay Rajpara1, Anthony Ormerod
1University of Aberdeen, Aberdeen, UK.
BMJ Clinical Evidence
|May 20, 2009
Summary
This systematic review evaluates treatments for basal cell carcinoma (BCC), the most common skin cancer. It assesses interventions for short-term treatment response and long-term recurrence, analyzing effectiveness and safety data.
Area of Science:
- Dermatology
- Oncology
- Evidence-Based Medicine
Background:
- Basal cell carcinoma (BCC) is the most prevalent skin cancer, primarily affecting the head and neck.
- While metastasis is rare, BCC can cause significant local tissue damage and morbidity.
- Incidence is rising, particularly in younger populations, potentially linked to increased sun exposure.
Purpose of the Study:
- To systematically review interventions for basal cell carcinoma (BCC).
- To evaluate treatment response and recurrence rates (short-term and long-term) following various interventions.
- To assess the safety and effectiveness of different BCC treatment modalities.
Main Methods:
- Systematic review of 11 studies including systematic reviews, RCTs, and observational studies.
- Searched major databases (Medline, Embase, Cochrane Library) up to February 2007.
- Included harms alerts from regulatory agencies (FDA, MHRA) and applied GRADE evaluation.
Main Results:
- Identified 11 studies meeting inclusion criteria for the systematic review.
- Evaluated the quality of evidence for various interventions using the GRADE system.
- Compiled data on the effectiveness and safety of multiple treatment options.
Conclusions:
- Presents information on the effectiveness and safety of cryotherapy/cryosurgery.
- Reviews curettage and cautery/electrodesiccation, fluorouracil, and imiquimod 5% cream.
- Summarizes findings for photodynamic therapy and surgical interventions (conventional and Moh's micrographic surgery).
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