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Increased Intracranial Pressure l: Introduction01:14

Increased Intracranial Pressure l: Introduction

Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

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Published on: June 2, 2014

Cluster headache.

Manjit Matharu1, Nicholas Silver

  • 1The Headache Group, Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK.

BMJ Clinical Evidence
|May 20, 2009
PubMed
Summary
This summary is machine-generated.

This systematic review evaluates treatments for cluster headache, a severe unilateral pain condition. It found 29 studies on interventions to abort and prevent attacks, providing evidence on their effectiveness and safety.

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Area of Science:

  • Neurology
  • Headache Medicine

Background:

  • Cluster headache is defined by the International Headache Society (IHS) criteria as severe, strictly unilateral orbital, supraorbital, or temporal pain attacks lasting 15-180 minutes.
  • Attacks occur frequently, ranging from once every other day to eight times daily.

Purpose of the Study:

  • To systematically review the effects of interventions for aborting and preventing cluster headache.
  • To assess the safety and effectiveness of various treatment options.

Main Methods:

  • Conducted a systematic literature review searching major databases up to September 2006.
  • Included data from 29 systematic reviews, randomized controlled trials (RCTs), and observational studies.
  • Incorporated harms alerts from regulatory agencies like the FDA and MHRA.

Main Results:

  • Evaluated the quality of evidence for interventions using the GRADE system.
  • Identified numerous interventions for cluster headache treatment.

Conclusions:

  • Presents information on the effectiveness and safety of a wide range of cluster headache interventions.
  • Includes pharmacological (e.g., sumatriptan, verapamil, topiramate) and non-pharmacological (e.g., oxygen therapy, nerve injections) treatments.