Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Diabetic Retinopathy

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

The Retina

The Retina

The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.

Anatomy of the Eyeball

Anatomy of the Eyeball

The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle layer, the vascular tunic,...

Photoreceptors and Visual Pathways

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Standardizing Measurement of Complete Retinal Pigment Epithelial and Outer Retinal Atrophy: Classification of Atrophy Meeting Report 8.

Ophthalmology. Retina·2026

Same author

Climate Change and Health.

Journal of multidisciplinary healthcare·2025

Same author

Anti-VEGF drugs compared with laser photocoagulation for the treatment of diabetic retinopathy: a systematic review and economic analysis.

Health technology assessment (Winchester, England)·2025

Same author

Poster Session: Leveraging AI to classify sex based on fovea shape features.

Journal of vision·2025

Same author

Anti-VEGF drugs compared with laser photocoagulation for the treatment of proliferative diabetic retinopathy: a systematic review and individual participant data meta-analysis.

Health technology assessment (Winchester, England)·2025

Same author

A systematic review of the cost-effectiveness of anti-VEGF drugs for the treatment of diabetic retinopathy.

Health technology assessment (Winchester, England)·2025

Same journal

Rheumatoid arthritis: previously untreated early disease.

BMJ clinical evidence·2016

Same journal

Diabetic retinopathy: intravitreal vascular endothelial growth factor inhibitors for diabetic macular oedema.

BMJ clinical evidence·2016

Same journal

Subarachnoid haemorrhage (spontaneous aneurysmal).

BMJ clinical evidence·2016

Same journal

Malaria: fluid therapy in severe disease.

BMJ clinical evidence·2016

Same journal

Age-related macular degeneration: anti-vascular endothelial growth factor treatment.

BMJ clinical evidence·2016

Same journal

MRSA: treating people with infection.

BMJ clinical evidence·2016

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 23, 2026

Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate

Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate

Published on: September 11, 2013

Retinal detachment.

David Steel¹, Scott Fraser

¹Sunderland Eye Infirmary, Sunderland, UK.

BMJ Clinical Evidence

|May 20, 2009

Summary

This summary is machine-generated.

This systematic review evaluates interventions for rhegmatogenous retinal detachment (RRD). It covers prevention, surgical treatments, and management of proliferative vitreoretinopathy, synthesizing evidence on effectiveness and safety.

More Related Videos

Efficient and Consistent Generation of Retinal Pigment Epithelium/Choroid Flatmounts from Human Eyes for Histological Analysis

Efficient and Consistent Generation of Retinal Pigment Epithelium/Choroid Flatmounts from Human Eyes for Histological Analysis

Published on: October 28, 2022

Intraoperative Visualization of Subretinal Injection and Retinal Detachment in Rats

Intraoperative Visualization of Subretinal Injection and Retinal Detachment in Rats

Published on: March 7, 2025

Related Experiment Videos

Last Updated: Jun 23, 2026

Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate

Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate

Published on: September 11, 2013

Efficient and Consistent Generation of Retinal Pigment Epithelium/Choroid Flatmounts from Human Eyes for Histological Analysis

Efficient and Consistent Generation of Retinal Pigment Epithelium/Choroid Flatmounts from Human Eyes for Histological Analysis

Published on: October 28, 2022

Intraoperative Visualization of Subretinal Injection and Retinal Detachment in Rats

Intraoperative Visualization of Subretinal Injection and Retinal Detachment in Rats

Published on: March 7, 2025

Area of Science:

Ophthalmology
Retinal Surgery
Evidence-Based Medicine

Background:

Rhegmatogenous retinal detachment (RRD) is a common condition where a retinal break leads to fluid ingress and retinal separation.
RRD affects approximately 1 in 10,000 individuals annually.

Purpose of the Study:

To systematically review interventions for preventing RRD progression from retinal breaks or lattice degeneration.
To evaluate the effectiveness of various surgical interventions for RRD.
To assess treatments for proliferative vitreoretinopathy (PVR) complicating RRD.

Main Methods:

Conducted a systematic literature review searching major databases up to September 2006.
Included systematic reviews, RCTs, and observational studies.
Incorporated safety alerts from regulatory agencies like the FDA and MHRA.

Main Results:

Identified 8 relevant systematic reviews, RCTs, or observational studies.
Performed a GRADE evaluation to assess the quality of evidence for interventions.

Conclusions:

Presents information on the effectiveness and safety of cryotherapy, laser photocoagulation, pneumatic retinopexy, scleral buckling, gas tamponade, and silicone oil vitrectomy.
Discusses interventions for PVR, including specific pharmacological agents during vitrectomy.