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Updated: Jun 23, 2026
09:29
Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
Published on: March 20, 2020
Breast cancer (non-metastatic)
Justin Stebbing1, Geoff Delaney, Alistair Thompson
1Chelsea and Westminister Hospital, London, UK.
BMJ Clinical Evidence
|May 20, 2009
Summary
This systematic review evaluates various breast cancer treatments, including chemotherapy, hormonal therapy, and radiotherapy, for different stages of operable and locally advanced disease. It synthesizes evidence on intervention effectiveness and safety to guide clinical decisions.
Area of Science:
- Oncology
- Clinical Medicine
- Evidence-Based Practice
Background:
- Breast cancer impacts at least 1 in 10 UK women.
- Most cases present as primary operable disease with an 80% 5-year survival rate.
- Effective treatment strategies are crucial for improving patient outcomes.
Purpose of the Study:
- To systematically review interventions for ductal carcinoma in situ after breast-conserving surgery.
- To evaluate treatments for primary operable breast cancer.
- To assess interventions for locally advanced breast cancer (stage IIIB).
Main Methods:
- Systematic review of literature up to February 2006.
- Searched Medline, Embase, and The Cochrane Library.
- Included harms alerts from regulatory agencies (FDA, MHRA).
Main Results:
- Included 79 systematic reviews, RCTs, and observational studies.
- Performed GRADE evaluation for evidence quality.
- Synthesized data on a wide range of interventions.
Conclusions:
- Presents information on effectiveness and safety of numerous breast cancer interventions.
- Covers chemotherapy, hormonal therapy, radiotherapy, and surgical techniques.
- Evidence synthesis aims to inform treatment choices for various breast cancer stages.
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