Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Trichomoniasis

Trichomoniasis

Trichomonas vaginalis is a flagellated protozoan parasite and the causative agent of trichomoniasis, one of the most prevalent non-viral sexually transmitted infections in the United States. This extracellular parasite primarily colonizes the lower genitourinary tract in women—particularly the vagina—and in men, the urethra and prostate. Its structural and functional adaptations enable its survival, motility, and pathogenicity within the host environment.Structural Features and Host EntryT.

Sexually Transmitted Infections

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...

Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

American Trypanosomiasis

American Trypanosomiasis

Chagas disease, or American trypanosomiasis, is a vector-borne parasitic infection caused by Trypanosoma cruzi, a flagellated protozoan (kinetoplastid) of the family Trypanosomatidae. The disease is endemic in Latin America, although cases are increasingly reported worldwide due to human migration. Transmission most commonly occurs when feces of infected triatomine bugs contaminate bite wounds or mucosal surfaces; additional routes include congenital, transfusional, transplant-related, and oral...

Bacterial Phylum Chlamydiae

Bacterial Phylum Chlamydiae

The phylum Chlamydiae or Chlamydiota is composed of a single order, Chlamydiales. This phylum consists entirely of obligate intracellular parasites that infect eukaryotic hosts. While human pathogens within this group have been studied extensively, the phylum encompasses many species capable of interacting with various eukaryotic organisms. Members of Chlamydiae are typically small cocci, approximately 0.5 μm in diameter, and exhibit a distinctive developmental cycle. As is characteristic of...

Microbiome of the Eye

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Evolutionary dynamics in the genome of ocular <i>Chlamydia trachomatis</i> strains from Northern Tanzania following mass drug administration.

Microbial genomics·2025

Same author

Cluster randomised controlled trial of double-dose azithromycin mass drug administration, facial cleanliness and fly control measures for trachoma control in Oromia, Ethiopia: the stronger SAFE trial protocol.

BMJ open·2024

Same author

Adjunctive ivermectin mass drug administration for malaria control on the Bijagos Archipelago of Guinea-Bissau (MATAMAL): a quadruple-blinded, cluster-randomised, placebo-controlled trial.

The Lancet. Infectious diseases·2024

Same author

Investigating SARS-CoV-2 Incidence and Morbidity in Ponce, Puerto Rico: Protocol and Baseline Results From a Community Cohort Study.

JMIR research protocols·2024

Same author

Genomic insights into local-scale evolution of ocular <i>Chlamydia trachomatis</i> strains within and between individuals in Gambian trachoma-endemic villages.

Microbial genomics·2024

Same author

Corneal pannus, Herbert's pits and conjunctival inflammation in older children in Papua New Guinea.

Ophthalmic epidemiology·2024

Same journal

Rheumatoid arthritis: previously untreated early disease.

BMJ clinical evidence·2016

Same journal

Diabetic retinopathy: intravitreal vascular endothelial growth factor inhibitors for diabetic macular oedema.

BMJ clinical evidence·2016

Same journal

Subarachnoid haemorrhage (spontaneous aneurysmal).

BMJ clinical evidence·2016

Same journal

Malaria: fluid therapy in severe disease.

BMJ clinical evidence·2016

Same journal

Age-related macular degeneration: anti-vascular endothelial growth factor treatment.

BMJ clinical evidence·2016

Same journal

MRSA: treating people with infection.

BMJ clinical evidence·2016

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 23, 2026

A Human Fallopian Tube Model for Investigation of C. trachomatis Infections

A Human Fallopian Tube Model for Investigation of C. trachomatis Infections

Published on: August 11, 2012

Trachoma.

Anthony Solomon¹, David Mabey

¹London School of Hygiene & Tropical Medicine, London, UK.

BMJ Clinical Evidence

|May 20, 2009

Summary

This summary is machine-generated.

This systematic review evaluates interventions to prevent scarring trachoma, a leading infectious cause of blindness. Findings cover antibiotics, hygiene, fly control, health education, and lid surgery effectiveness.

More Related Videos

Surgical Correction for Pediatric Epiblepharon and Trichiasis

Surgical Correction for Pediatric Epiblepharon and Trichiasis

Published on: July 8, 2025

Related Experiment Videos

Last Updated: Jun 23, 2026

A Human Fallopian Tube Model for Investigation of C. trachomatis Infections

A Human Fallopian Tube Model for Investigation of C. trachomatis Infections

Published on: August 11, 2012

Surgical Correction for Pediatric Epiblepharon and Trichiasis

Surgical Correction for Pediatric Epiblepharon and Trichiasis

Published on: July 8, 2025

Area of Science:

Ophthalmology
Infectious Diseases
Public Health

Background:

Active trachoma, caused by Chlamydia trachomatis, is the primary infectious cause of blindness globally.
The disease leads to conjunctival scarring, trichiasis (inward-growing eyelashes), and corneal opacity.
Trachoma disproportionately affects populations in poverty with poor sanitation, with children experiencing active disease and adults at higher risk of scarring.

Purpose of the Study:

To systematically review the effectiveness of interventions aimed at preventing scarring trachoma by reducing active infection.
To assess the efficacy of eyelid surgery for entropion and trichiasis in managing trachoma complications.

Main Methods:

A systematic review of 23 studies, including systematic reviews, randomized controlled trials (RCTs), and observational studies, was conducted.
Searches were performed across major databases (Medline, Embase, The Cochrane Library) up to January 2006.
GRADE evaluation was used to assess the quality of evidence for the included interventions.

Main Results:

The review identified evidence on various interventions for trachoma prevention and management.
Studies included assessments of antibiotics, face washing, fly control measures, health education, and surgical procedures.

Conclusions:

The systematic review provides information on the effectiveness and safety of interventions including antibiotics, hygiene practices, fly control, health education, and lid surgery.
These interventions are crucial for controlling trachoma and preventing associated blindness.