Related Experiment Video
Updated: Jun 23, 2026

07:34
Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System
Published on: May 5, 2018
Fetal-to-neonatal transition--what is normal and what is not?
Neonatal Network : NN
|May 20, 2009
Summary
This review covers the physiological changes from fetal to newborn life. It highlights key warning signs for delayed transition, disease, congenital issues, or birth injuries in infants.
Area of Science:
- Neonatal physiology
- Perinatal adaptations
- Infant health
Background:
- The transition from fetal to neonatal circulation is a critical period.
- Understanding normal physiologic adaptations is essential for identifying deviations.
- Newborn infants are vulnerable to various complications during this transition.
Purpose of the Study:
- To review the physiological adaptations during fetal to neonatal transition.
- To identify common red flags indicating delayed transition or adverse outcomes.
- To inform healthcare providers on recognizing potential neonatal issues.
Main Methods:
- Literature review of physiologic changes in newborns.
- Analysis of clinical indicators for delayed transition.
- Synthesis of information on congenital abnormalities and birth injuries.
Main Results:
- Detailed description of cardiovascular, respiratory, and metabolic shifts.
- Identification of specific clinical signs associated with delayed adaptation.
- Categorization of red flags related to congenital conditions and birth trauma.
Conclusions:
- Early recognition of deviations from normal transition is crucial.
- Awareness of red flags aids in timely diagnosis and intervention.
- This review provides a framework for assessing neonatal well-being.
Related Concept Videos
Fetal Circulation
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Transcytosis of IgG
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...

