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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published on: June 3, 2016
Adiposity and mortality in type 1 diabetes.
B Conway1, R G Miller, T Costacou
1Department of Epidemiology, The University of Pittsburgh, Pittsburgh, PA 15217, USA.
International Journal of Obesity (2005)
|May 20, 2009
Summary
In type 1 diabetes (T1D), adiposity now shows a U-shaped link with mortality, similar to the general population. However, being underweight significantly increases mortality risk in T1D patients.
Area of Science:
- Endocrinology
- Epidemiology
- Metabolic Diseases
Background:
- Adiposity typically has a J- or U-shaped association with mortality in the general population, but this can be linear in catabolic states.
- An increase in overweight and obesity has been observed in type 1 diabetes (T1D) patients, potentially linked to intensified insulin therapy (IIT).
Purpose of the Study:
- To investigate the association between adiposity and mortality in individuals with T1D.
- To examine how changes in body mass index (BMI) over time influence mortality risk in T1D.
Main Methods:
- Utilized data from 655 participants in the Pittsburgh Epidemiology of Diabetes Complications Study (EDC) over 20 years.
- Categorized participants by BMI (underweight, normal, overweight, obese) and employed Cox models with baseline, updated, and time-varying BMI measures.
Main Results:
- The prevalence of IIT increased significantly, alongside substantial rises in overweight and obesity.
- Time-varying BMI models revealed a U-shaped relationship between adiposity and mortality, with underweight individuals facing higher risk.
- Weight gain during follow-up was found to be protective, and waist circumference adjustment mitigated risk in obese individuals.
Conclusions:
- The adiposity-mortality relationship in T1D now mirrors the general population's pattern.
- A significantly elevated mortality risk is evident in underweight T1D individuals.
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