Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Three-Dimensional Microscopy in Microbiology01:28

Three-Dimensional Microscopy in Microbiology

Three-dimensional imaging techniques are essential in cell biology, allowing researchers to visualize intricate cellular structures with high resolution. Two prominent methods, Differential Interference Contrast Microscopy (DIC) and Confocal Scanning Laser Microscopy (CSLM), provide distinct advantages for imaging live and thick specimens, respectively.Differential Interference Contrast MicroscopyDIC microscopy enhances contrast in transparent, unstained samples by converting phase...
Electron Microscope Tomography and Single-particle Reconstruction01:07

Electron Microscope Tomography and Single-particle Reconstruction

Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Angiosomes of the medial femoral condyle: Anatomical study of cutaneous perforators.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2026
Same author

Rethinking Morton's neuroma: a sonographic study of bilateral prevalence and symmetry.

Journal of orthopaedic surgery and research·2026
Same author

Development of the membranous labyrinth in E9.5 to E14.5 C57BL/6N mouse embryos. Stage specific metric and descriptive reference data and their use for identifying malformations.

Frontiers in cell and developmental biology·2026
Same author

Comparative validation of oxidative bisulfite sequencing (oxBS) and chemical-assisted pyridine borane sequencing (CAPS) protocols for locus-specific 5-hydroxymethylcytosine quantification.

Epigenetics & chromatin·2026
Same author

The re-establishment of medical education in Lviv: a Habsburg legacy of politics, architecture, mand academic exchange.

Folia morphologica·2026
Same author

Radial Artery Occlusion Impairs Median Nerve Perfusion-A Study Using Microvascular Imaging in Healthy Volunteers.

Diagnostics (Basel, Switzerland)·2026
Same journal

RNA Modifications as Drug Targets: Unlocking the Therapeutic Potential of the Epitranscriptome.

Current genomics·2026
Same journal

AgriBioNER: A Named Entity Recognition Tool for Identification of ncRNA and Diseases in Agricultural Literature.

Current genomics·2026
Same journal

Understanding the Evolutionary Adaptations and the Associated Functional Dynamics of Diatom <i>Cyclotella Cryptica</i>: A Chloroplast Genome-wide Comparative Study.

Current genomics·2026
Same journal

The Role of Collagen Genetic Variability in Degenerative Disc Disease and Related Conditions.

Current genomics·2026
Same journal

Genomics-Driven Immunotherapy: Advancing Cancer Treatment through Personalized Approaches.

Current genomics·2026
Same journal

Innovative Applications and Challenges of Isothermal Amplification Technology in miRNA Detection.

Current genomics·2026
See all related articles

Related Experiment Video

Updated: Jun 23, 2026

Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation
12:59

Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation

Published on: February 28, 2021

Episcopic 3D Imaging Methods: Tools for Researching Gene Function.

Wolfgang J Weninger1, Stefan H Geyer

  • 1IMG, Centre for Anatomy and Cell Biology, Medical University of Vienna, Waehringer Str. 13, A-1090 Vienna, Austria.

Current Genomics
|May 20, 2009
PubMed
Summary
This summary is machine-generated.

Episcopic 3D imaging offers high-resolution insights into embryo development and disease. This powerful technique analyzes gene expression and tissue structure, aiding research into genetic mechanisms and pathologies.

Keywords:
3D modellingdevelopmentembryoepiscopic microscopygene expression.imaging

More Related Videos

Rapid Acquisition of 3D Images Using High-resolution Episcopic Microscopy
07:27

Rapid Acquisition of 3D Images Using High-resolution Episcopic Microscopy

Published on: November 21, 2016

High-resolution Episcopic Microscopy (HREM) - Simple and Robust Protocols for Processing and Visualizing Organic Materials
08:52

High-resolution Episcopic Microscopy (HREM) - Simple and Robust Protocols for Processing and Visualizing Organic Materials

Published on: July 7, 2017

Related Experiment Videos

Last Updated: Jun 23, 2026

Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation
12:59

Three and Four-Dimensional Visualization and Analysis Approaches to Study Vertebrate Axial Elongation and Segmentation

Published on: February 28, 2021

Rapid Acquisition of 3D Images Using High-resolution Episcopic Microscopy
07:27

Rapid Acquisition of 3D Images Using High-resolution Episcopic Microscopy

Published on: November 21, 2016

High-resolution Episcopic Microscopy (HREM) - Simple and Robust Protocols for Processing and Visualizing Organic Materials
08:52

High-resolution Episcopic Microscopy (HREM) - Simple and Robust Protocols for Processing and Visualizing Organic Materials

Published on: July 7, 2017

Area of Science:

  • Developmental Biology
  • Biomedical Imaging
  • Genetics

Background:

  • Episcopic 3D imaging methods are advancing rapidly.
  • These techniques generate high-resolution volume data for embryos and tissue samples.

Purpose of the Study:

  • To describe episcopic 3D imaging methods.
  • To discuss their contribution to researching genetic mechanisms in embryogenesis, tissue remodeling, and pathologies.

Main Methods:

  • Utilizing advanced episcopic 3D imaging to generate high-resolution volume data.
  • Integrating whole-mount in situ hybridization and immunohistochemical staining for 3D gene expression analysis.
  • Applying techniques to analyze phenotypes of genetically engineered or malformed embryos.

Main Results:

  • High-resolution 3D analysis of anatomy, tissue architecture, and gene expression patterns.
  • Successful application in studying malformed embryos and spatial gene distribution during development.
  • Potential for analyzing adult human and animal tissues for disease research, including cancer staging.

Conclusions:

  • Episcopic 3D imaging is an emerging methodology with significant potential.
  • It is becoming an indispensable tool for studying genetic regulation in development and disease genesis.
  • Further research is needed to establish routine clinical applications.