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Published on: June 28, 2019

Coronary flow slows as renal function worsens

Mehmet Birhan Yilmaz1, Kenan Yalta

  • 1Department of Cardiology, Cumhuriyet University School of Medicine, Sivas, Turkey.

Clinical Cardiology
|May 20, 2009
PubMed

Insights

Impaired renal function is linked to slower coronary blood flow in individuals without obstructive coronary artery disease. This study found an independent association between reduced kidney function and coronary flow, measured by Thrombolysis In Myocardial Infarction (TIMI) frame counts.

Area of Science:

  • Cardiology
  • Nephrology
  • Diagnostic Imaging

Background:

  • Slow coronary flow (SCF) is an angiographic finding in patients without obstructive coronary artery disease, detectable by Thrombolysis In Myocardial Infarction (TIMI) frame counts.
  • Impaired renal function (IRF) is a common clinical problem.
  • The relationship between SCF and IRF requires further investigation.

Purpose of the Study:

  • To evaluate the impact of impaired renal function on slow coronary flow in patients with normal coronary arteries.
  • To determine if there is an independent association between renal function and coronary flow.

Main Methods:

  • 105 patients with impaired renal function (calculated glomerular filtration rate [GFR] < 90 mL/min/1.73 m²) and normal coronary arteries were enrolled.
  • 102 age- and sex-matched controls with normal GFR were used for comparison.
  • Thrombolysis In Myocardial Infarction (TIMI) frame counts were used to assess coronary flow.

Main Results:

  • A significant negative correlation was observed between calculated GFR and TIMI frame counts in the left anterior descending (LAD), circumflex (CX), and right coronary artery (RCA) in patients with IRF.
  • Multiple regression analysis, after adjusting for blood pressure and HDL cholesterol, confirmed an independent relationship between TIMI frame count and GFR.
  • These findings suggest that lower GFR is associated with slower coronary flow.

Conclusions:

  • Impaired renal function is associated with slower coronary flow in patients with normal coronary arteries.
  • An independent association exists between GFR and TIMI frame count in individuals with impaired renal function.
  • These results highlight a potential link between kidney health and coronary circulation.
Abstract

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