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Effect of experimental ocular hypertension on macrovacuolation in Schlemm's canal endothelial cells of monkey eyes
M Nakabayashi1, K Kishida, H Okazaki
1Department of Ophthalmology, Kinan Hospital, Wakayama, Japan.
Abstract:
The severance of all the extraocular muscles (tenotomy) caused temporary ocular hypertension, lasting a few days, in Japanese monkey (Macaca fuscata) eyes. We studied the morphology of Schlemm's canal endothelium of the eyes under a light microscope after quick fixation through continuous irrigation of the anterior chamber with a 10% acrolein solution, with precise control of the hydrostatic pressure on the eyes during fixation. A statistically significant increase in macrovacuolation in endothelial cells of Schlemm's canal of normal eyes was observed when additional hydrostatic pressure was applied. However, such an increase was not observed in the case of tenotomized temporary hypertensive eyes.