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Updated: Jun 23, 2026

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
Published on: January 22, 2019
Research on the bioactivities of C60-dexamethasone
Ruili Liu1, Xiaoqing Cai, Jiandong Wang
1Laboratory of Nano-Biology and Medicine, Shanghai Institute of Applied Physics, Chinese Academy of Science, Shanghai 201800, China.
Abstract:
The bioactivities, including the anti-inflammatory activity and influences on the learning function and the immunosuppression activity, of C60-dexamethasone have been studied in mice and compared with those of dexamethasone. C60-dexamethasone and dexamethasone were administered orally at dosage of 30 micromol/kg x d. The experiments showed that C60-dexamethasone retained the anti-inflammatory activity. On the other side the influences of C60-dexamethasone on the learning function and the immunosuppression activity were much lower than that of dexamethasone. The scavenging test for lipophilic DPPH free radical indicated that C60-dexamethasone was an efficient free radical remover or antioxidant, which was responsible for the reduction of side effects of C60-dexamethasone.
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