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Updated: Jun 23, 2026

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
A new, facile, and general synthesis of functional and heterodifunctional ferrocenes
Abdou K Diallo1, Jaime Ruiz, Didier Astruc
1Institut des Sciences Moleculaires, UMR CNRS No. 5255, Universite Bordeaux 1, 33405 Talence Cedex, France.
Abstract:
A new, very simple, and general method for the synthesis of functional and heterodifunctional 1,1'-ferrocenes is reported using the visible-light photolysis of a simple 100-W desk lamp with the easily available complexes [(eta(5)-C(5)H(4)R)Fe(eta(6)-toluene)][PF(6)] (R = Me, Cl, COMe, CO(2)H, CO(2)Me, CO(2)CH(2)CCH, CONHCH(2)Ph) and a substituted cyclopentadienyl salt MC(5)H(4)R' (M = Li, Na, R' = H, COMe, CO(2)Me, SiMe(2)CH(2)Cl, PPh(2)) under ambient conditions. All the reactions give high yields except when the side chain contains a strong ligand competing with the Cp anion complexation.
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