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Comparison of propofol-fentanyl with propofol-fentanyl-ketamine combination in pediatric patients undergoing

I Aydin Erden1, A Gulsun Pamuk, Seda B Akinci

  • 1Department of Anaesthesiology and Reanimation, Hacettepe University, Sihhiye, Ankara 06100, Turkey. aydinerden@yahoo.com

Paediatric Anaesthesia
|May 21, 2009
PubMed

Insights

Adding ketamine to propofol and fentanyl sedation for pediatric interventional radiology procedures reduced oxygen desaturation events. This combination also lowered the need for additional propofol, improving patient recovery.

Area of Science:

  • Pediatric Anesthesiology
  • Interventional Radiology
  • Pharmacology

Background:

  • Interventional radiology procedures in children are increasing.
  • Procedural sedation is crucial for these pediatric interventions.
  • Optimizing sedation regimens is essential for patient safety and procedural success.

Purpose of the Study:

  • To compare adverse effects, sedation levels, and recovery in pediatric patients receiving propofol-fentanyl with or without ketamine.
  • To test the hypothesis that ketamine addition reduces propofol/fentanyl-induced desaturation.

Main Methods:

  • A randomized, double-blinded study of 60 pediatric patients (ASA physical status I-III).
  • Group 1: propofol + fentanyl + ketamine.
  • Group 2: propofol + fentanyl + saline placebo.

Main Results:

  • Oxygen desaturation occurred in 10% of patients receiving ketamine versus 30% without ketamine (P=0.052).
  • Fewer patients required supplemental propofol in the ketamine group (40% vs. 70%, P=0.021).
  • No significant differences in other side effects, except for nystagmus.

Conclusions:

  • Low-dose ketamine added to propofol-fentanyl decreases desaturation risk in pediatric interventional radiology.
  • Ketamine addition also reduces the need for supplemental propofol, enhancing sedation efficacy.
Abstract

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