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Metastasis

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Related Experiment Video

Updated: Jun 23, 2026

A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer

A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer

Published on: December 26, 2016

Breast cancer (metastatic).

Justin Stebbing¹, Sarah Slater, Maurice Slevin

¹The Hammersmith Hospitals NHS Trust, Department of Medical Oncology, Charing Cross Hospital, London, UK.

BMJ Clinical Evidence

|May 21, 2009

Summary

Metastatic breast cancer survival varies greatly; treatments like hormonal therapy, chemotherapy, and targeted therapies show effectiveness. This review synthesizes evidence on various interventions for metastatic breast cancer.

Area of Science:

Oncology
Medical Treatment Efficacy

Background:

Metastatic breast cancer median survival is 12 months without treatment.
Survival can extend up to 20 years in young patients, unlike other metastatic cancers.
This highlights the need for effective treatment strategies.

Purpose of the Study:

To systematically review the effects of first- and second-line hormonal treatments.
To evaluate the impact of first- and second-line chemotherapy, alone or with monoclonal antibodies.
To assess treatments for bone, spinal cord, and brain metastases.

Main Methods:

Conducted a systematic review of medical literature up to June 2006.
Searched Medline, Embase, The Cochrane Library, and other databases.
Included harms alerts from regulatory agencies like the FDA and MHRA.

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Generating a Murine Orthotopic Metastatic Breast Cancer Model and Performing Murine Radical Mastectomy

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Surgical Procedures and Methodology for a Preclinical Murine Model of De Novo Mammary Cancer Metastasis

Published on: July 29, 2017

Related Experiment Videos

Last Updated: Jun 23, 2026

A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer

A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer

Published on: December 26, 2016

Generating a Murine Orthotopic Metastatic Breast Cancer Model and Performing Murine Radical Mastectomy

Generating a Murine Orthotopic Metastatic Breast Cancer Model and Performing Murine Radical Mastectomy

Published on: November 29, 2018

Surgical Procedures and Methodology for a Preclinical Murine Model of De Novo Mammary Cancer Metastasis

Surgical Procedures and Methodology for a Preclinical Murine Model of De Novo Mammary Cancer Metastasis

Published on: July 29, 2017

Main Results:

Identified 63 systematic reviews, RCTs, and observational studies meeting inclusion criteria.
Synthesized data on a wide range of interventions for metastatic breast cancer.
Provided evidence on the effectiveness and safety of numerous treatment options.

Conclusions:

Presents information on the effectiveness and safety of diverse interventions.
Includes hormonal therapies (tamoxifen, progestins, aromatase inhibitors), chemotherapy regimens (anthracycline-based, taxane-based), and targeted therapy (trastuzumab).
Covers treatments for metastases, including bisphosphonates, radiotherapy, and surgery.