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Published on: January 26, 2019
Measles, mumps, and rubella: prevention.
David Elliman1, Nitu Sengupta, Haitham El Bashir
1Islington PCT and Great Ormond Street Hospital, London, UK.
BMJ Clinical Evidence
|May 21, 2009
Summary
Measles, mumps, and rubella (MMR) vaccination significantly reduces infection risks and complications. This review evaluates the effectiveness and safety of MMR and monovalent vaccines, highlighting the importance of vaccination programs.
Area of Science:
- Public Health
- Infectious Diseases
- Vaccinology
Background:
- Measles, mumps, and rubella cause millions of infections and deaths globally.
- These diseases pose risks of severe complications, including neurological issues, infertility, and congenital abnormalities.
- Decreased vaccination rates correlate with increased disease incidence.
Purpose of the Study:
- To systematically review the effects of measles, mumps, and rubella vaccination.
- To evaluate the effectiveness and safety of MMR and monovalent vaccines.
Main Methods:
- Systematic review of 94 studies including systematic reviews, RCTs, and observational studies.
- Searched major databases (Medline, Embase, Cochrane Library) up to July 2006.
- Included harms alerts from regulatory agencies like the FDA and MHRA.
Main Results:
- Identified 94 relevant studies meeting inclusion criteria.
- Performed GRADE evaluation to assess the quality of evidence for interventions.
Conclusions:
- Presents information on the effectiveness and safety of measles, mumps, and rubella vaccines.
- Supports the use of vaccination programs to control these infectious diseases.
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