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Related Concept Videos

Oogenesis02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
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Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity
07:20

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity

Published on: December 21, 2012

Endometriosis.

Neil Johnson1, Cynthia Farquhar

  • 1University of Auckland, Auckland, New Zealand.

BMJ Clinical Evidence
|May 21, 2009
PubMed
Summary
This summary is machine-generated.

This systematic review evaluates hormonal and non-hormonal treatments for endometriosis, including surgical options. It provides evidence on the effectiveness and safety of various interventions for managing this condition.

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Area of Science:

  • Reproductive Medicine
  • Gynecology
  • Surgical Innovation

Background:

  • Endometriosis affects up to 60% of women with dysmenorrhea and 30% with subfertility.
  • Peak incidence of endometriosis occurs around age 40.
  • Symptoms of endometriosis may not correlate with laparoscopic findings.

Purpose of the Study:

  • To systematically review the effects of hormonal treatments at diagnosis and before/after surgery for endometriosis.
  • To evaluate non-hormonal medical and surgical treatments for endometriosis.
  • To assess treatments for ovarian endometrioma.

Main Methods:

  • Systematic review of 32 studies including systematic reviews, RCTs, and observational studies.
  • Searched Medline, Embase, The Cochrane Library up to April 2006.
  • Included harms alerts from FDA and MHRA.

Main Results:

  • Evaluated the quality of evidence for various endometriosis interventions using GRADE.
  • Included studies on combined oral contraceptives, danazol, progestogens, GnRH analogues, NSAIDs, and surgical procedures.
  • Assessed hormonal treatments before and after surgery, and treatments for ovarian endometrioma.

Conclusions:

  • Presents information on the effectiveness and safety of multiple endometriosis interventions.
  • Includes hormonal treatments (e.g., oral contraceptives, progestogens) and surgical options (e.g., laparoscopic cystectomy, presacral neurectomy).
  • Provides a comprehensive overview of available treatments for endometriosis.