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Endolymphatic Duct Blockage as a Surgical Treatment Option for Ménière's Disease

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Menière's disease.

Adrian L James¹, Marc A Thorp

¹Department of Otolaryngology, Southmead Hospital, Bristol, UK.

BMJ Clinical Evidence

|May 21, 2009

Summary

This summary is machine-generated.

This systematic review examines treatments for Menière

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In Vivo Morphometric Analysis of Human Cranial Nerves Using Magnetic Resonance Imaging in Menière's Disease Ears and Normal Hearing Ears

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In Vivo Morphometric Analysis of Human Cranial Nerves Using Magnetic Resonance Imaging in Menière's Disease Ears and Normal Hearing Ears

In Vivo Morphometric Analysis of Human Cranial Nerves Using Magnetic Resonance Imaging in Menière's Disease Ears and Normal Hearing Ears

Published on: February 21, 2018

Area of Science:

Otolaryngology
Neurology
Pharmacology

Background:

Menière's disease is a progressive, fluctuating inner ear disorder affecting adults aged 40-60.
Characterized by recurrent vertigo, hearing loss, tinnitus, and ear fullness.
Symptoms often occur in clusters, with vertigo typically resolving but hearing loss progressing.

Purpose of the Study:

To systematically review treatments for acute Menière's disease attacks.
To evaluate interventions aimed at preventing attacks and slowing disease progression.

Main Methods:

Conducted a systematic literature review up to January 2006.
Searched major databases including Medline, Embase, and The Cochrane Library.
Included studies like systematic reviews, RCTs, and observational studies, with GRADE evaluation of evidence quality.

Main Results:

Identified 17 systematic reviews, RCTs, or observational studies meeting inclusion criteria.
Evaluated the quality of evidence for various interventions using the GRADE system.
Included harms alerts from regulatory agencies like the FDA and MHRA.

Conclusions:

Presents information on the effectiveness and safety of numerous interventions.
Interventions reviewed include anticholinergics, benzodiazepines, betahistine, cinnarizine, dietary modification, diuretics, phenothiazines, psychological support, trimetazidine, and vestibular rehabilitation.