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Related Concept Videos

Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Irritable Bowel Syndrome01:23

Irritable Bowel Syndrome

DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility PatternsDisordered...
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...

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Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
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Irritable bowel syndrome.

Niek de Wit1, Gregory Rubin, Roger Hugh Jones

  • 1Julius Center for Health Sciences and Primary Care, University Medical Center, Universiteitsweg, Utrecht, The Netherlands.

BMJ Clinical Evidence
|May 21, 2009
PubMed
Summary
This summary is machine-generated.

This systematic review examines treatments for irritable bowel syndrome (IBS). It evaluated various interventions, including medications and therapies, to determine their effectiveness and safety for IBS patients.

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Area of Science:

  • Gastroenterology
  • Clinical Medicine
  • Evidence-Based Practice

Background:

  • Irritable bowel syndrome (IBS) affects 5-15% of the population, linked to gut dysfunction, perception, and psychosocial factors.
  • IBS patients show higher rates of cholecystectomy and hysterectomy.

Purpose of the Study:

  • To systematically review the effects of various treatments for irritable bowel syndrome (IBS).

Main Methods:

  • Conducted a systematic literature search across major databases up to June 2006.
  • Included data from systematic reviews, RCTs, and observational studies.
  • Incorporated safety alerts from regulatory agencies like the FDA and MHRA.

Main Results:

  • Identified 23 relevant systematic reviews, RCTs, or observational studies.
  • Performed GRADE evaluations to assess the quality of evidence for interventions.
  • Gathered data on the effectiveness and safety of multiple IBS treatments.

Conclusions:

  • The review presents findings on the effectiveness and safety of numerous IBS interventions.
  • Interventions evaluated include 5HT receptor antagonists/agonists, antidepressants, antispasmodics, CBT, hypnotherapy, fiber, and loperamide.