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Genital Herpes

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Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...

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Related Experiment Video

Updated: Jun 23, 2026

Isolation of Lymphocytes from Mouse Genital Tract Mucosa

Isolation of Lymphocytes from Mouse Genital Tract Mucosa

Published on: September 3, 2012

Genital herpes.

Eva Maria Agnes Jungmann¹

¹Camden PCT, London, UK.

BMJ Clinical Evidence

|May 21, 2009

Summary

This summary is machine-generated.

This systematic review examines interventions for genital herpes (HSV-1 and HSV-2), a common STD. It evaluates treatments for sexual transmission, mother-to-neonate spread, first episodes, recurrences, and co-infection with HIV.

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Detection of the Genome and Transcripts of a Persistent DNA Virus in Neuronal Tissues by Fluorescent In situ Hybridization Combined with Immunostaining

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Area of Science:

Infectious Diseases
Virology
Public Health

Background:

Genital herpes is a prevalent sexually transmitted disease caused by herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2).
Understanding effective interventions is crucial for disease control and management.

Purpose of the Study:

To systematically review the effects of interventions aimed at preventing sexual transmission of genital herpes.
To assess interventions for preventing mother-to-neonate transmission.
To evaluate antiviral treatment efficacy for first episodes, recurrence reduction, and management in patients with HIV.

Main Methods:

A comprehensive systematic review was conducted, searching major databases including Medline, Embase, and The Cochrane Library up to August 2006.
Included studies comprised systematic reviews, randomized controlled trials (RCTs), and observational studies.
Harms alerts from regulatory agencies like the FDA and MHRA were also incorporated.

Main Results:

The review identified 35 relevant systematic reviews, RCTs, or observational studies.
A GRADE evaluation was performed to assess the quality of evidence for various interventions.
Data on effectiveness and safety of multiple interventions were compiled.

Conclusions:

The systematic review synthesizes evidence on interventions including antivirals (oral acyclovir), caesarean delivery, condoms, psychotherapy, recombinant glycoprotein vaccines, serological screening, and counselling.
These interventions address various aspects of genital herpes management, from prevention to treatment of recurrences and co-infections.