Related Experiment Video
Updated: Jun 23, 2026
10:14
Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
Age related macular degeneration
Jennifer J Arnold1, Wilson Heriot
1Marsden Eye Specialists, Parramatta, New South Wales, Australia.
BMJ Clinical Evidence
|May 21, 2009
Summary
This systematic review evaluates interventions for age-related macular degeneration (AMD). It found various treatments, including antiangiogenesis and antioxidant vitamins, with effectiveness and safety data presented for late-stage AMD progression.
Area of Science:
- Ophthalmology
- Medical Interventions
- Systematic Reviews
Background:
- Age-related macular degeneration (AMD) affects 2% of individuals over 50, increasing with age.
- Early AMD shows retinal changes like drusen, while late AMD causes central vision loss.
- Peripheral vision is typically preserved in both early and late stages of AMD.
Purpose of the Study:
- To systematically review interventions for preventing age-related macular degeneration (AMD) progression.
- To assess the effects of treatments for early-stage and late-stage AMD.
- To evaluate interventions for exudative AMD.
Main Methods:
- Conducted a systematic review of medical literature up to March 2006.
- Searched major databases including Medline, Embase, and The Cochrane Library.
- Included 45 systematic reviews, RCTs, and observational studies, assessing evidence quality with GRADE.
Main Results:
- Identified numerous studies meeting inclusion criteria for AMD interventions.
- Evaluated the effectiveness and safety of various treatments.
- Included harms alerts from regulatory agencies like the FDA and MHRA.
Conclusions:
- Presents information on the effectiveness and safety of multiple AMD interventions.
- Covers antiangiogenesis therapies (pegaptanib, ranibizumab, etc.).
- Discusses antioxidant vitamins with zinc, radiation, laser treatments, photodynamic therapy, surgery, and thermotherapy.
More Related Videos
Related Concept Videos
01:27Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
01:22Photoreceptors and Visual Pathways
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
01:29Alzheimer Disease l: Introduction
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
01:22Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
01:22iPS Cell Differentiation
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.