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Related Concept Videos

Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Appendicitis01:19

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:

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Related Experiment Video

Updated: Jun 23, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

Appendicitis.

David Humes1, William James Speake, John Simpson

  • 1University of Nottingham, Nottingham, UK.

BMJ Clinical Evidence
|May 21, 2009
PubMed
Summary
This summary is machine-generated.

This systematic review evaluates treatments for acute appendicitis, the most common surgical emergency. It found 10 studies on interventions like antibiotics and surgery, assessing their effectiveness and safety.

Related Experiment Videos

Last Updated: Jun 23, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

Area of Science:

  • Gastroenterology
  • Surgical Emergency Management
  • Evidence-Based Medicine

Background:

  • Appendicitis, a common cause of abdominal surgical emergencies, can stem from lumen obstruction by faecoliths, lymphoid hyperplasia, or caecal carcinoma.
  • The lifetime risk of appendicitis in the USA is 7-9%, with mortality rates of <0.3% that increase to 1.7% post-perforation.
  • Acute appendicitis necessitates prompt diagnosis and management due to potential severe complications.

Purpose of the Study:

  • To systematically review and synthesize the evidence on the effects of various treatments for acute appendicitis.
  • To answer the clinical question regarding the efficacy and safety of interventions for acute appendicitis.
  • To provide an evidence-based overview of surgical and non-surgical treatment options.

Main Methods:

  • Conducted a systematic review of literature up to November 2006, searching major medical databases.
  • Included 10 systematic reviews, randomized controlled trials (RCTs), and observational studies meeting inclusion criteria.
  • Utilized the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system to evaluate the quality of evidence for interventions.

Main Results:

  • Identified and analyzed data from 10 relevant studies evaluating different appendicitis treatments.
  • Included a comprehensive assessment of harms from regulatory agencies like the FDA and MHRA.
  • The review synthesized findings on the effectiveness and safety of multiple interventions.

Conclusions:

  • Presents information on the effectiveness and safety of key interventions for acute appendicitis.
  • Highlights the range of treatments evaluated, including antibiotics, laparoscopic surgery, open surgery, ligation, and stump inversion.
  • Provides a foundation for understanding current treatment options based on available evidence.