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Related Experiment Video

Updated: Jun 23, 2026

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
05:39

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

Published on: November 30, 2021

Infantile colic.

Peter Lucassen1

  • 1Department of general practice, Radbound University Nijmegen, Nijmegen, The Netherlands.

BMJ Clinical Evidence
|May 21, 2009
PubMed
Summary
This summary is machine-generated.

Infantile colic affects many families, prompting healthcare consultations. This systematic review evaluates various treatments for infant colic, assessing their effectiveness and safety based on current evidence.

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Last Updated: Jun 23, 2026

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
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Area of Science:

  • Pediatrics
  • Evidence-Based Medicine

Background:

  • Infantile colic is a common condition affecting approximately 17% of families with infants.
  • Prevalence varies significantly based on study design and data collection methods.

Purpose of the Study:

  • To systematically review and evaluate the effects of various treatments for infantile colic.
  • To answer the clinical question regarding the efficacy and safety of infantile colic interventions.

Main Methods:

  • Conducted a systematic review of medical literature up to January 2007.
  • Searched major databases including Medline, Embase, and The Cochrane Library.
  • Included harms alerts from regulatory agencies like the FDA and MHRA.

Main Results:

  • Identified 23 relevant systematic reviews, randomized controlled trials (RCTs), and observational studies.
  • Performed a GRADE evaluation to assess the quality of evidence for different interventions.
  • Compiled information on the effectiveness and safety of numerous treatments.

Conclusions:

  • Presents findings on interventions such as casein hydrolysate milk, infant massage, and simethicone.
  • Covers a range of treatments including cranial osteopathy, gripe water, and dietary modifications.
  • Provides a comprehensive overview of evidence for infantile colic treatments.