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Urinary tract infection in children

James Larcombe1

  • 1NHSE Northern and Yorkshire, Sedgefield, UK.

BMJ Clinical Evidence
|May 21, 2009
PubMed

Insights

Urinary tract infections (UTIs) are common in children, with recurrence frequent. This review evaluates antibiotic treatments and surgical interventions for pediatric UTIs and vesicoureteric reflux to improve outcomes.

Area of Science:

  • Pediatric Nephrology
  • Urology
  • Evidence-Based Medicine

Background:

  • Urinary tract infections (UTIs) affect a significant percentage of children, with high rates of recurrence.
  • Vesicoureteric reflux (VUR) is frequently diagnosed in children with UTIs and is a risk factor for renal scarring.

Purpose of the Study:

  • To systematically review the effects of treating acute UTIs in children.
  • To evaluate interventions aimed at preventing recurrent UTIs in pediatric populations.

Main Methods:

  • Conducted a systematic review of literature up to December 2006.
  • Included data from systematic reviews, randomized controlled trials (RCTs), and observational studies.
  • Incorporated safety alerts from regulatory agencies like the FDA and MHRA.

Main Results:

  • Identified 27 relevant studies meeting inclusion criteria.
  • Performed a GRADE evaluation to assess the quality of evidence for various interventions.
  • Synthesized information on the effectiveness and safety of different treatment modalities.

Conclusions:

  • The review provides comprehensive information on the effectiveness and safety of antibiotic therapies for pediatric UTIs.
  • Evaluated surgical interventions for both functional abnormalities and moderate to severe VUR.
  • Offers evidence-based guidance for managing pediatric UTIs and associated conditions.
Abstract

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