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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

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Related Experiment Video

Updated: Jun 23, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Asthma in adults.

Rodolfo J Dennis1, Ivan Solarte, J Mark Fitzgerald

  • 1Head, Departments of Medicine and Research, Fundacion Cardioinfantil Instituto de Cardiologia, Bogota, Colombia.

BMJ Clinical Evidence
|May 21, 2009
PubMed
Summary
This summary is machine-generated.

This systematic review evaluates treatments for acute and chronic asthma, presenting evidence on interventions for severe and mild-to-moderate disease. It covers various therapies, including medications and supportive care, to inform asthma management strategies.

Related Experiment Videos

Last Updated: Jun 23, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Area of Science:

  • Pulmonology
  • Clinical Medicine
  • Pharmacology

Background:

  • Asthma affects 10% of adults, with 5% experiencing severe, treatment-resistant disease, increasing mortality risk.
  • Even mild to moderate asthma carries a risk of exacerbations, necessitating effective management strategies.
  • Current asthma management often relies on stepwise protocols, but evidence for specific interventions requires systematic evaluation.

Purpose of the Study:

  • To systematically review the evidence on the effectiveness and safety of various treatments for chronic and acute asthma.
  • To provide clinicians with a comprehensive overview of interventions for different asthma severities.
  • To inform clinical decision-making by presenting GRADE-evaluated evidence for asthma therapies.

Main Methods:

  • A systematic review was conducted, searching major databases (Medline, Embase, Cochrane Library) up to October 2006.
  • Included studies comprised systematic reviews, randomized controlled trials (RCTs), and observational studies.
  • Harms alerts from regulatory agencies like the FDA and MHRA were also incorporated.

Main Results:

  • 121 studies meeting inclusion criteria were identified and evaluated.
  • Evidence quality for interventions was assessed using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system.
  • Findings cover a wide range of acute and chronic asthma interventions.

Conclusions:

  • Effectiveness and safety data are presented for numerous acute asthma interventions, including beta(2) agonists, corticosteroids, and oxygen supplementation.
  • For chronic asthma, the review details evidence for beta(2) agonists, inhaled corticosteroids, leukotriene antagonists, and theophylline.
  • The review provides a foundation for understanding the evidence base of various asthma treatments, aiding in management decisions.