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Updated: Jun 23, 2026
04:05
A Rat Model of Pouchitis Following Proctocolectomy and Ileal Pouch-Anal Anastomosis Using Dextran Sulfate Sodium
Published on: May 31, 2024
Summary
This systematic review examines non-surgical and surgical treatments for chronic anal fissures. It found evidence on interventions like botulinum toxin and internal anal sphincterotomy, evaluating their effectiveness and safety.
Area of Science:
- Gastroenterology
- Colorectal Surgery
Background:
- Anal fissures are a frequent cause of defecation-related anal pain.
- Low dietary fiber intake is a potential risk factor for anal fissures.
Purpose of the Study:
- To systematically review the effects of non-surgical treatments for chronic anal fissure.
- To systematically review the effects of surgical treatments for chronic anal fissure.
Main Methods:
- A systematic review of Medline, Embase, and The Cochrane Library was conducted.
- Included studies were assessed for quality using the GRADE system.
- Harms alerts from regulatory agencies were also incorporated.
Main Results:
- Eleven systematic reviews, RCTs, or observational studies met the inclusion criteria.
- The GRADE system was used to evaluate the quality of evidence for various interventions.
Conclusions:
- Information on the effectiveness and safety of multiple interventions is presented.
- Interventions reviewed include anal advancement flap, anal stretch/dilation, botulinum A toxin, calcium channel blockers, internal anal sphincterotomy, and nitric oxide donors.
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