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Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
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Colonic diverticular disease.

David Humes1, John Simpson, Robin C Spiller

  • 1Department of Surgery, University of Nottingham, Nottingham, UK.

BMJ Clinical Evidence
|May 21, 2009
PubMed
Summary
This summary is machine-generated.

This systematic review examines treatments for diverticular disease, including uncomplicated cases, complication prevention, and acute diverticulitis. Evidence on interventions like fiber, antispasmodics, and surgery is evaluated for effectiveness and safety.

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Area of Science:

  • Gastroenterology
  • Colorectal Surgery
  • Evidence-Based Medicine

Background:

  • Diverticula affect over 5% of adults over 40, with 10-25% experiencing symptoms.
  • Recurrent symptoms are common, and 5% develop serious complications like perforation or hemorrhage.

Purpose of the Study:

  • To systematically review treatments for uncomplicated diverticular disease.
  • To assess interventions for preventing diverticular disease complications.
  • To evaluate treatments for acute diverticulitis.

Main Methods:

  • Systematic review of studies up to July 2006.
  • Searched Medline, Embase, The Cochrane Library, and other databases.
  • Included harms alerts from regulatory agencies (FDA, MHRA).

Main Results:

  • Included 13 systematic reviews, RCTs, or observational studies.
  • Evaluated the quality of evidence for various interventions using GRADE.
  • Identified interventions such as antispasmodics, bran, surgery, and fiber intake.

Conclusions:

  • Presents information on the effectiveness and safety of multiple interventions for diverticular disease.
  • Covers treatments ranging from dietary fiber to medical and surgical options.
  • Provides a comprehensive overview for managing diverticular disease and its complications.