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Otitis media in children (acute)
Paddy O'Neill1, Tony Roberts, Clare Bradley Stevenson
1Norton Medical Centre, Stockton on Tees, UK.
Insights
Acute otitis media (AOM) in children often resolves without antibiotics. This review evaluates treatments and prevention strategies for AOM, considering effectiveness and safety to guide clinical decisions.
Area of Science:
- Pediatrics
- Infectious Diseases
- Evidence-Based Medicine
Background:
- Acute otitis media (AOM) is a common childhood illness, frequently treated with antibiotics.
- High antibiotic prescription rates for AOM in the UK and USA are noted.
- Many AOM cases resolve spontaneously without antibiotic intervention.
Purpose of the Study:
- To systematically review the effects of various treatments for AOM in children.
- To evaluate interventions aimed at preventing recurrent AOM.
- To provide evidence-based information for clinical practice regarding AOM management.
Main Methods:
- Conducted a systematic review of medical literature up to January 2007.
- Searched major databases including Medline, Embase, and The Cochrane Library.
- Included data from 19 systematic reviews, randomized controlled trials (RCTs), and observational studies.
- Incorporated safety alerts from regulatory agencies like the FDA and MHRA.
Main Results:
- Identified and evaluated evidence for multiple AOM interventions.
- Assessed the quality of evidence using the GRADE system.
- Information gathered pertains to the effectiveness and safety of treatments and preventive measures.
Conclusions:
- The review synthesizes information on the effectiveness and safety of interventions for AOM.
- Interventions discussed include analgesics, antibiotics (immediate, delayed, prophylactic, longer courses), myringotomy, pneumococcal vaccination, and tympanostomy tubes.
- Findings aim to inform treatment and prevention strategies for pediatric AOM.
Introduction:
In the UK, about 30% of children under 3 years of age visit their GPs each year with acute otitis media (AOM), and 97% of these receive antibiotics. In the USA, AOM is the most common reason for outpatient antibiotic treatment. Without antibiotics, AOM resolves within 24 hours in about 60% of children, and within 3 days in about 80% of children.
Methods And Outcomes:
We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of treatments for AOM in children; and what are the effects of interventions to prevent recurrence? We searched: Medline, Embase, The Cochrane Library and other important databases up to January 2007. (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
Results:
We found 19 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
Conclusions:
In this systematic review we present information relating to the effectiveness and safety of the following interventions: analgesics, antibiotics, delayed antibiotics, immediate antibiotics, long-term antibiotic prophylaxis, longer courses of antibiotics, myringotomy, pneumococcal vaccination, tympanostomy with ventilation tubes.
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