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Published on: April 1, 2019
The angiotensin converting enzyme gene I/D polymorphism in Polish rowers
P Cieszczyk1, K Krupecki, A Maciejewska
1Institute of Physical Culture, University of Szczecin, Szczecin, Poland.
International Journal of Sports Medicine
|May 21, 2009
Summary
The Angiotensin Converting Enzyme (ACE) gene
Area of Science:
- Sports Science
- Genetics
- Physiology
Background:
- The Angiotensin Converting Enzyme (ACE) gene plays a crucial role in the renin-angiotensin system, regulating blood pressure.
- ACE gene polymorphisms are frequently studied for their association with athletic predispositions.
- Understanding ACE genotype associations can provide insights into elite athletic performance.
Purpose of the Study:
- To investigate the association between ACE gene polymorphism and athletic performance in Polish rowers.
- To test the hypothesis that specific ACE genotypes correlate with endurance capabilities in athletes.
- To compare ACE genotype frequencies in elite rowers versus a control population.
Main Methods:
- DNA samples from 55 elite Polish rowers and 115 healthy volunteers were analyzed.
- Polymerase Chain Reaction (PCR) was used to identify insertion (I) or deletion (D) alleles of the ACE gene.
- Genotype distributions and allele frequencies were calculated and compared using chi-squared analysis.
Main Results:
- A significant difference in the frequency of the I allele was observed between rowers (56.3%) and controls (44.3%) (P=0.038).
- The overall ACE genotype distribution in the rower group differed significantly from the control group (P=0.039).
- The study found a higher prevalence of the II genotype in elite rowers compared to controls.
Conclusions:
- The I allele of the ACE gene is positively associated with endurance performance in athletes.
- ACE gene polymorphism is a significant genetic factor influencing athletic success in endurance sports like rowing.
- These findings support the role of the ACE gene in determining physiological traits relevant to elite athletic performance.
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