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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Efficient syntheses of crispine A and harmicine by RH-catalyzed cyclohydrocarbonylation
Wen-Hua Chiou1, Gau-Hong Lin, Che-Cheng Hsu
1Department of Chemistry, National Chung Hsing University, Taichung, Taiwan, ROC. wchiou@dragon.nchu.edu.tw
Abstract:
The first examples of Rh-catalyzed cyclohydrocarbonylation-bicyclization of N-allylic amides of arylacetic acids are reported. This novel carbonylative bicyclization process was successfully applied to the rapid syntheses of crispine A and its analogues (tricyclic indolizidine alkaloids) as well as harmicine (tetracyclic beta-carboline alkaloid).
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