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Related Experiment Video

Updated: Jun 23, 2026

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy
07:13

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy

Published on: May 27, 2020

Caffeine reduces resting-state BOLD functional connectivity in the motor cortex.

Anna Leigh Rack-Gomer1, Joy Liau, Thomas T Liu

  • 1Center for Functional Magnetic Resonance Imaging, University of California San Diego, La Jolla, CA 92093-0677, USA.

Neuroimage
|May 22, 2009
PubMed
Summary

Caffeine intake significantly reduced resting-state functional connectivity in the motor cortex. This common stimulant also decreased cerebral blood flow and low-frequency BOLD signal energy, impacting fMRI study interpretations.

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Area of Science:

  • Neuroimaging
  • Cognitive Neuroscience
  • Pharmacology

Background:

  • Resting-state functional magnetic resonance imaging (fMRI) measures brain functional connectivity via blood oxygenation level dependent (BOLD) signal fluctuations.
  • BOLD signal interpretation is complex, influenced by both neural activity and vascular factors.
  • Vasoactive substances like caffeine can alter BOLD signal dynamics, potentially affecting connectivity measures.

Purpose of the Study:

  • To investigate the impact of a 200 mg caffeine dose on resting-state BOLD connectivity in the motor cortex.
  • To determine if caffeine affects baseline cerebral blood flow and the spectral energy of low-frequency BOLD fluctuations.

Main Methods:

  • Recruited a sample of 9 healthy young subjects.
  • Administered a 200 mg dose of caffeine.

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Last Updated: Jun 23, 2026

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy
07:13

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Published on: May 27, 2020

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  • Utilized resting-state fMRI to measure BOLD signal fluctuations in the motor cortex.
  • Analyzed functional connectivity, cerebral blood flow, and spectral energy.

    • Main Results:

    • Caffeine significantly reduced resting-state BOLD connectivity in the motor cortex (p<0.05).
    • A significant decrease in baseline cerebral blood flow was observed post-caffeine.
    • Caffeine also significantly decreased spectral energy in the low-frequency BOLD fluctuations.

    Conclusions:

    • Caffeine consumption alters resting-state BOLD connectivity, particularly in the motor cortex.
    • The observed changes in cerebral blood flow and BOLD signal energy suggest a vascular mechanism for caffeine's effect.
    • Researchers should consider caffeine intake when designing and interpreting resting-state fMRI studies.