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Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
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Bleeding in acute promyelocytic leukemia (APL): fibrinolysis or defibrination?

I Krsnik1, A Escribá, M López-Rubio

  • 1Servicio de Hematología, Hospital Clínico de San Carlos, Madrid, Espagne.

Nouvelle Revue Francaise D'Hematologie
|January 1, 1991
PubMed

The coagulation abnormalities in 20 cases of acute promyelocytic leukemia (APL) treated at a single institution were reviewed. A remarkably uniform picture of defibrination and increased FDPs with well-preserved levels of other coagulation factors including AT-III was seen. Our data, together with those available in the literature, do not support DIC as the underlying mechanism of bleeding but seem rather to point to increased proteolysis as the cause.

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