Related Experiment Video
Updated: Jun 23, 2026
09:56
In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model
Published on: January 21, 2018
Spatially consistent, localized visual field loss before and after disc hemorrhage.
Carlos Gustavo V De Moraes1, Tiago S Prata, Craig A Liebmann
1Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York, USA.
Investigative Ophthalmology & Visual Science
|May 22, 2009
Summary
Disc hemorrhage in glaucoma is linked to faster visual field loss in specific areas. This localized progression continues after hemorrhage detection, indicating ongoing damage.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Visual Field Analysis
Background:
- Glaucoma is a leading cause of irreversible blindness.
- Disc hemorrhage (DH) is a known risk factor for glaucoma progression.
- Understanding the relationship between DH and visual field (VF) loss is crucial for patient management.
Purpose of the Study:
- To evaluate the rate and location of visual field (VF) progression before and after the detection of disc hemorrhage (DH) in glaucoma patients.
Main Methods:
- Disc photographs of glaucoma patients with sufficient VF data were analyzed for DH.
- Automated pointwise linear regression calculated global and localized VF progression rates.
- Progression rates were compared before and after DH detection and with fellow eyes.
Main Results:
- Localized VF progression was observed in the sector preceding DH detection.
- Progression rates significantly increased after DH detection in the same VF sector.
- The fastest VF progression predicted future DH location in 85% of cases.
Conclusions:
- Rapid, localized VF loss precedes and predicts the location of disc hemorrhage.
- Progressive VF loss continues at an accelerated rate in the same sector post-DH.
- This suggests localized disease progression drives DH and subsequent vision loss.
