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Related Experiment Video

Updated: Jun 23, 2026

Solvent Bonding for Fabrication of PMMA and COP Microfluidic Devices
04:54

Solvent Bonding for Fabrication of PMMA and COP Microfluidic Devices

Published on: January 17, 2017

Plastic-PDMS bonding for high pressure hydrolytically stable active microfluidics.

Kevin S Lee1, Rajeev J Ram

  • 1Massachusetts Institute of Technology, 26-459, 32 Vassar St., Cambridge, MA 02139, USA. kevbolee@mit.edu

Lab on a Chip
|May 22, 2009
PubMed
Summary

Organofunctional silanes enhance plastic-to-PDMS membrane bonding for microfluidic devices. Optimized silane chemistry improves bond strength in aqueous conditions, enabling robust microfluidic applications.

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Area of Science:

  • Materials Science
  • Chemical Engineering
  • Microfluidics

Background:

  • Microfluidic devices often require robust bonding between dissimilar materials like plastics and polydimethylsiloxane (PDMS) membranes.
  • Achieving durable bonds, especially in aqueous environments, is crucial for device functionality and longevity.
  • Organofunctional silanes offer a potential solution for creating strong, hydrolytically stable interfaces.

Purpose of the Study:

  • To investigate the use of organofunctional silanes for bonding plastic substrates to PDMS membranes.
  • To enhance the bond strength and hydrolytic stability of plastic-PDMS interfaces in microfluidic applications.
  • To evaluate the performance of these bonds under operational stress in aqueous environments.

Main Methods:

  • Fabrication of a test device using polycarbonate (PC) and PDMS membranes.

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High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods
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High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

Published on: December 23, 2013

Non-plasma Bonding of PDMS for Inexpensive Fabrication of Microfluidic Devices
04:45

Non-plasma Bonding of PDMS for Inexpensive Fabrication of Microfluidic Devices

Published on: November 1, 2007

Related Experiment Videos

Last Updated: Jun 23, 2026

Solvent Bonding for Fabrication of PMMA and COP Microfluidic Devices
04:54

Solvent Bonding for Fabrication of PMMA and COP Microfluidic Devices

Published on: January 17, 2017

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods
07:51

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

Published on: December 23, 2013

Non-plasma Bonding of PDMS for Inexpensive Fabrication of Microfluidic Devices
04:45

Non-plasma Bonding of PDMS for Inexpensive Fabrication of Microfluidic Devices

Published on: November 1, 2007

  • Application of isopropoxy modified bis-trimethoxy-silyl-propyl-amine for bonding.
  • Testing of valve performance under pressure (up to 60 psi) in aqueous conditions.
  • Long-term pumping tests with DI water, 1 M HCl, and 1 M NaOH at 18 psi.

    • Main Results:

    • The developed bonding method using specific bis-silanes demonstrated robust performance in aqueous environments.
    • Microfluidic valves operated successfully up to 60 psi without failure.
    • Sustained operation with DI water and 1 M HCl for two weeks at 18 psi showed no bond degradation.
    • Bond failure was observed only when exposed to 1 M NaOH after 115 hours.

    Conclusions:

    • Organofunctional silanes, particularly bis-silanes with optimized end groups, significantly improve the hydrolytic stability of plastic-PDMS bonds.
    • The developed bonding strategy enables the fabrication of reliable actuated membrane microfluidics in plastic devices for various applications.
    • Further optimization may be needed for applications involving highly alkaline environments.