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Dandruff: infection or not?

N J Abbe1, D Head, J V Reed

  • 1Beecham Products Research Department, Weybridge, Surrey, U.K.

International Journal of Cosmetic Science
|May 23, 2009
PubMed
Summary
This summary is machine-generated.

Dandruff scaling appears linked to scalp microflora, particularly yeasts like Pityrosporum, which thrive on sebum. Effective dandruff control requires targeting these microbes within hair follicles, not just epidermal cell turnover.

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Area of Science:

  • Dermatology
  • Microbiology
  • Biochemistry

Background:

  • Dandruff scales contain normal corneocytes and parakeratotic material, suggesting recent keratinization changes.
  • Sebum production and lipolysis within hair follicles after puberty are implicated.
  • Colonization by fat-splitting microorganisms, especially Pityrosporum yeasts, plays a role.

Purpose of the Study:

  • To investigate the generation of dandruff scaling.
  • To understand the role of scalp microflora in dandruff.
  • To evaluate the mechanisms of antidandruff efficacy.

Main Methods:

  • Analysis of dandruff scales for cellular material.
  • Investigation of microbial colonization and sebum lipolysis.
  • Assessment of antidandruff compound properties (in vitro and in vivo).

Main Results:

  • Dandruff generation involves Pityrosporum yeasts and fatty acids from sebum lipolysis.
  • Antidandruff efficacy requires antifungal potency and penetration to hair follicles.
  • Antimicrobial activity against scalp microflora is key, more so than anti-hyperproliferative effects.

Conclusions:

  • Scalp microflora, particularly yeasts, are predominant in generating dandruff.
  • Antidandruff treatments should target microbial activity within hair follicles.
  • The primary mechanism for dandruff control is antimicrobial action.