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Published on: February 16, 2020

Chemokine IP-10: an adjunct marker for latent tuberculosis infection in children

Jennifer Lighter1, M Rigaud, M Huie

  • 1Saul Krugman Division of Pediatric Infectious Diseases and Immunology, New York University School of Medicine, New York, New York 10016, USA. lightj03@med.nyu.edu

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
|May 23, 2009
PubMed

Insights

Chemokine inducible protein 10 (IP-10) shows promise for diagnosing Mycobacterium tuberculosis infection in children. Combining IP-10 with interferon-gamma (IFN-γ) may improve diagnostic accuracy, particularly in young children.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Diagnostics

Background:

  • Chemokine inducible protein 10 (IP-10) has been implicated in Mycobacterium tuberculosis (M. tuberculosis) infection.
  • Elevated IP-10 levels are observed in plasma and at infection sites in individuals with M. tuberculosis.

Purpose of the Study:

  • To assess IP-10 as a diagnostic marker for M. tuberculosis infection in children.
  • To evaluate IP-10 in a low tuberculosis (TB) prevalence region.

Main Methods:

  • Whole blood from 127 children was stimulated with M. tuberculosis-specific antigens to measure IP-10 levels.
  • IP-10 results were analyzed against TB exposure risk, tuberculin skin test, and interferon-gamma release assay (IGRA).

Main Results:

  • IP-10 reactivity correlated with M. tuberculosis exposure risk and IGRA results.
  • IP-10 responses were not age-dependent and identified more positive cases in children under 5 years old compared to interferon-gamma (IFN-γ).
  • IGRA demonstrated higher sensitivity than IP-10 in detecting active M. tuberculosis disease.

Conclusions:

  • IP-10, when used with IFN-γ, may enhance the diagnostic performance of IGRAs for M. tuberculosis infection.
  • This combination is particularly beneficial for diagnosing TB in young children.
Abstract

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