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Related Experiment Video

Updated: Jun 23, 2026

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke
09:10

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Published on: February 22, 2020

Hidden dysfunctioning in subacute stroke.

Assia Jaillard1, Bernadette Naegele, Sandra Trabucco-Miguel

  • 1Institut Fédératif de Recherche, Unité d'Imagerie par Résonance Magnétique, IRF 1-Pôle Imagerie, CHU Grenoble, Grenoble, France. Assia.Jaillard@ujf-grenoble.fr

Stroke
|May 23, 2009
PubMed
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This summary is machine-generated.

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Cognitive dysfunctioning (CDF) is highly prevalent after stroke, particularly affecting working memory (WM). Early assessment of WM in mild stroke patients is crucial for rehabilitation and return to work.

Area of Science:

  • Neuroscience
  • Neurology
  • Cognitive Psychology

Background:

  • Cognitive dysfunctioning (CDF) after stroke significantly impacts patient recovery and return to previous activities.
  • Previous studies show variability in CDF rates in subacute stroke, necessitating further investigation.
  • This study focuses on identifying hidden CDF in subacute stroke patients without dementia.

Purpose of the Study:

  • To determine the frequency and detailed neuropsychological profile of cognitive dysfunctioning (CDF) in patients with subacute stroke.
  • To identify specific cognitive domains and tests most indicative of CDF.
  • To explore factors associated with CDF in this population.

Main Methods:

  • A prospective cohort of 177 patients with first-ever ischemic stroke (Mini-Mental State Examination score ≥23) were assessed two weeks post-stroke.

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Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke
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  • A comprehensive battery of tests evaluated four cognitive domains: instrumental functions, executive functions, episodic memory, and working memory (WM).
  • Patients' cognitive scores were compared to age- and education-matched controls using Z-scores, with logistic regression identifying key predictors of CDF.

    • Main Results:

    • Over 91% of patients exhibited CDF in at least one cognitive domain.
    • Working memory (WM) was the most affected domain (87.6%), followed by executive functions (64.4%) and episodic memory (64.4%).
    • Logistic regression identified WM tests (Modified Paced Auditorial Serial Addition Test, Owen-spatial-WM) and age as significant predictors of CDF.

    Conclusions:

    • Cognitive dysfunctioning (CDF) is nearly universal, though often underestimated, in subacute stroke patients.
    • Impaired working memory (WM) may underlie hidden cognitive deficits impacting rehabilitation and return to work.
    • Routine inclusion of WM tests is recommended for young patients with mild stroke to facilitate timely intervention.