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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Primary cutaneous blastoid mantle cell lymphoma-case report.
Bruna Estrozi1, José A Sanches, Paulo C S Varela
1Pathology Reference Laboratory, Botucatu, São Paulo, Brazil.
The American Journal of Dermatopathology
|May 23, 2009
Summary
Primary cutaneous blastoid mantle cell lymphoma (BV-MCL), a rare aggressive variant, can originate in the skin. This case highlights BV-MCL presenting as a primary skin tumor with characteristic immunophenotype and genetic translocation.
Area of Science:
- Hematology
- Oncology
- Dermatopathology
Background:
- Mantle cell lymphoma (MCL) typically presents as disseminated disease involving extranodal sites.
- Primary cutaneous MCL is a rare manifestation, and its aggressive blastoid variant (BV-MCL) is even rarer.
- BV-MCL is associated with a more aggressive clinical course.
Observation:
- This report details a unique case of BV-MCL arising primarily in the skin.
- The tumor exhibited the characteristic immunophenotype of BV-MCL: CD20+, CD5+, cyclin D1+, CD23-, and CD10-.
- Genetic analysis revealed the hallmark t(11;14) translocation.
Findings:
- The study confirms that BV-MCL can present as a primary cutaneous neoplasm.
- The observed immunophenotype and genetic translocation align with established criteria for BV-MCL.
- This case expands the known clinical presentations of mantle cell lymphoma.
Implications:
- Recognizing primary cutaneous BV-MCL is crucial for accurate diagnosis and appropriate treatment planning.
- This finding may prompt further investigation into the pathogenesis of cutaneous lymphomas.
- Understanding rare presentations aids in improving patient outcomes for mantle cell lymphoma.
