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Updated: Jun 23, 2026
11:08
Chemo-enzymatic Synthesis of N-glycans for Array Development and HIV Antibody Profiling
Published on: February 5, 2018
New development of glycan arrays
Chung-Yi Wu1, Pi-Hui Liang, Chi-Huey Wong
1The Genomics Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan. cyiwu@gate.sinica.edu.tw
Organic & Biomolecular Chemistry
|May 23, 2009
Summary
Glycan arrays offer sensitive analysis of carbohydrate-protein interactions, advancing glycomics. These tools aid in medical diagnostics, pathogen detection, and developing carbohydrate-based vaccines for cancer and infections.
Area of Science:
- Carbohydrate chemistry
- Glycomics
- Biotechnology
Background:
- Glycan arrays facilitate high-sensitivity, high-throughput analysis of carbohydrate-protein interactions.
- Significant advancements in glycomics have been driven by glycan array technology.
- Recent developments include new array platforms for analyzing mono- and multivalent interactions on surfaces.
Purpose of the Study:
- To highlight the capabilities and applications of glycan array technology.
- To showcase glycan arrays as tools for basic research and medical diagnostics.
- To underscore the role of glycan arrays in developing novel vaccines.
Main Methods:
- Development of novel glycan array platforms.
- Qualitative and quantitative analysis of carbohydrate-protein interactions.
- Application of glycan arrays in diagnostics and vaccine design.
Main Results:
- Established glycan arrays as powerful tools for analyzing molecular interactions.
- Demonstrated the utility of glycan arrays in diverse fields, including diagnostics and therapeutics.
- Facilitated the design of carbohydrate-based vaccines.
Conclusions:
- Glycan arrays are essential for advancing glycomics and understanding biological processes.
- Glycan array technology holds significant promise for medical applications, including disease detection and vaccine development.
- Continued innovation in array platforms will further expand their utility in research and medicine.
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