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Updated: Jun 23, 2026
Preparation of Silica Nanoparticles Through Microwave-assisted Acid-catalysis
Published on: December 16, 2013
Assessment and use of two silicon carbide multi-well plates for library synthesis and proteolytic digests using
Lauren M Stencel1, Chad M Kormos, Keri B Avery
1Department of Chemistry, University of Connecticut, 55 North Eagleville Rd, Storrs, CT 06269-3060, USA.
Abstract:
The use of two silicon carbide plates is reported for the preparation of three libraries of organic molecules using microwave heating. In addition, a preliminary study has been carried out, showing that one of the plates can also be used in a proteomics setting. Both the 24-position and 48-position plates heated evenly when irradiated with microwave energy. The 48-position plate was used to prepare a library of N-aryl functionalized beta-amino esters via an aza-Michael reaction between anilines and Michael acceptors. The 24-position plate was used to prepare a library of biaryls via a Suzuki coupling methodology and a library of 1,4-dihydropyridines via a Hantzsch synthesis. The 48-position plate was also used to perform the proteolytic digestion of insulin chain B by trypsin.
