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Physiology of the Gastrointestinal System III: Elimination01:26

Physiology of the Gastrointestinal System III: Elimination

The gastrointestinal elimination process involves a complex interplay of neural and hormonal mechanisms that coordinate the final waste removal from the body. This intricate operation encompasses the absorption of water and electrolytes, vital for transforming the remaining indigestible food matter into feces. The large intestine is pivotal in water and electrolyte absorption, forming feces from unabsorbed minerals, undigested food, bacteria, bile pigments, and shed epithelial cells. Essential...
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Physiology of the Gastrointestinal System I: Ingestion and Propulsion01:22

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Physiology of the Gastrointestinal System II: Digestion and Absorption

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[NUTRITIONAL STATUS IN THE EXPERIMENT WITH 105-DAY ISOLATION AS THE FIRST PHASE OF PROJECT MARS-500].

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicineĀ·2016
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[Analysis of possible causes activation a stomach and pancreas excretory and incretory function after completion of space flight on the international space station].

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[Evaluation of the liver functional changes due to modeling the hemodynamic effects of microgravity in bed rest studies].

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Culturing Lymphocytes in Simulated Microgravity Using a Rotary Cell Culture System
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[Digestive system functioning during simulation of the microgravity effects on humans by immersion].

B V Afonin, E A Sedova

    Aviakosmicheskaia I Ekologicheskaia Meditsina = Aerospace and Environmental Medicine
    |May 26, 2009
    PubMed
    Summary

    Seven-day dry immersion significantly impacts digestive system function, increasing stomach, pancreas, and liver secretions. This study reveals changes in gastrointestinal electrical activity similar to those seen in space flight.

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    Published on: July 25, 2016

    Area of Science:

    • Gastroenterology
    • Human Physiology
    • Space Medicine

    Background:

    • Understanding the physiological effects of microgravity or simulated microgravity is crucial for astronaut health.
    • Dry immersion is a validated model for simulating microgravity's effects on the human body.

    Purpose of the Study:

    • To investigate the functional changes in the digestive system during a 7-day dry immersion period.
    • To analyze the impact on secretory activities and gastrointestinal (GI) electrical activity.

    Main Methods:

    • 10 healthy volunteers participated in a 7-day dry immersion study.
    • Measurements included secretory activities of the stomach, pancreas, and liver.
    • Spectral indices of GI electrical activity were analyzed.

    Main Results:

    • Dry immersion elevated secretory activities of the stomach, pancreas, and liver.
    • Increased spectral indices of GI electrical activity were observed.
    • Insular secretion was higher, while gastrin secretion was lower.
    • Changes in GI electrical activity resembled those induced by caffeine, bed rest, or space flight.

    Conclusions:

    • Simulated microgravity via dry immersion significantly alters digestive system function.
    • Observed GI changes suggest potential implications for nutrition and health in prolonged space missions.
    • Further research is needed to understand the long-term consequences and potential countermeasures.