[Studies of individual patterns of blood proteins control during simulation of the microgravity effects on humans]

Blood samples taken from test-subjects in the 7-d immersion experiment were analyzed for blood proteins belonging to alpha1- and alpha2-globulins electrophoretic fractions: alphal-antitripsin (alpha1-AT), a1-acidic glycoprotein (alpha1-AGP), ceruplasmin (Cer), haptoglobin (Hp), alpha2-macroglobulin (alpha2-M), apolipoprotein A (ApoA). Immersion was demonstrated to alter concentrations of the studied proteins; besides, it was shown that return to the normal state could also affect protein concentrations. Immersion effects on blood proteins patterned after acute reaction. Temporal profiles of alpha1-AGP, Cer, alpha2-M, Hp and ApoA were identical in all the test-subjects. Differences were mostly in the speed and amplitude of concentrations shifting. However, alpha1-AT showed a diversity of trends, whereas ApoA was common to all the subjects, three of them had this protein dropped below the bottom reference range. In two of these subject, baseline ApoA concentrations were also significantly lower in comparison to the others. These results infer that monitoring of blood alpha1-AT and ApoA in the period of adaptation to a changed environment may provide information useful for assessment of individual adaptability.