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Long-term experience of surgical treatment for aortic regurgitation attributable to Behçet's disease

Dong Seop Jeong1, Kyung-Hwan Kim, Jun Sung Kim

  • 1Department of Thoracic and Cardiovascular Surgery, Seoul National University Borame Medical Center, Seoul, South Korea.

The Annals of Thoracic Surgery
|May 26, 2009
PubMed

Insights

Cardiac involvement in Behçet

Area of Science:

  • Cardiology
  • Vascular Surgery
  • Rheumatology

Background:

  • Cardiac involvement in Behçet's disease is a rare but severe complication.
  • It presents challenges to cardiac surgeons due to potential late valve detachment or pseudoaneurysms.
  • Few reports detail surgical outcomes for aortic regurgitation in Behçet's disease.

Purpose of the Study:

  • To analyze clinical data and surgical outcomes in patients with aortic regurgitation caused by Behçet's disease.

Main Methods:

  • Nineteen patients with Behçet's disease-related aortic regurgitation underwent surgical treatment.
  • Data collected included patient demographics, surgical procedures, and follow-up durations (mean 77.4 months).
  • Outcomes were analyzed in relation to surgical approach and postoperative inflammatory markers.

Main Results:

  • Overall mortality was high at 47.3%, with all deaths occurring after second operations.
  • Aortic root replacement showed significantly better 13-year event-free survival (39.2%) than valve replacement (4%).
  • Postoperative immunosuppressive therapy was associated with improved event-free survival (33.7% vs. 0%).

Conclusions:

  • Mortality for cardiac involvement in Behçet's disease is very high and linked to postoperative inflammation.
  • Aortic root replacement may offer better long-term outcomes compared to valve replacement.
  • Postoperative immunosuppressive therapy appears beneficial in managing this condition.
Abstract

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