The calculus of integrating differentiation: timing control of T-bet

Mark Boothby1

  • 1Departments of Microbiology & Immunology and Medicine, Vanderbilt University School of Medicine, 1161 21(st) Avenue South, Nashville, TN 37232-2363, USA. mark.boothby@vanderbilt.edu

Immunity
|May 26, 2009
PubMed

In this issue of Immunity, Schulz et al. (2009) use mathematical modeling to elucidate a signaling network controlling Ifng gene expression, thereby showing the importance of an Interleukin-12-dependent, Interferon-gamma-independent second phase of inducing the transcription factor T-bet.

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