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Updated: Jun 22, 2026

Mouse in Utero Electroporation: Controlled Spatiotemporal Gene Transfection
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AhR-mediated gene expression in the developing mouse telencephalon.

Julia M Gohlke1, Pat S Stockton, Stella Sieber

  • 1Environmental Systems Biology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, RTP, NC 27709, USA.

Reproductive Toxicology (Elmsford, N.Y.)
|May 26, 2009
PubMed
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Polychlorinated dibenzodioxins and furans (TCDD) disrupt brain development by interfering with the aryl hydrocarbon receptor (AhR). This interference specifically impacts GABAergic neuron differentiation in the developing telencephalon.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Toxicology

Background:

  • Developmental neurotoxicity of environmental contaminants is a significant public health concern.
  • The aryl hydrocarbon receptor (AhR) is a key mediator of toxicant responses, including those of TCDD.
  • Understanding AhR's role in neurodevelopment is crucial for assessing chemical risks.

Purpose of the Study:

  • To investigate the role of AhR in TCDD-induced developmental neurotoxicity.
  • To examine the impact of TCDD on gene expression during telencephalon development.
  • To identify specific neuronal differentiation pathways affected by AhR signaling.

Main Methods:

  • Global gene expression analysis in E13.5 mouse telencephalon (dorsal and ventral).
  • Comparison of TCDD-exposed wildtype and AhR knockout (AhR-/-) mice.

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Last Updated: Jun 22, 2026

Mouse in Utero Electroporation: Controlled Spatiotemporal Gene Transfection
09:30

Mouse in Utero Electroporation: Controlled Spatiotemporal Gene Transfection

Published on: August 15, 2011

Genetic Manipulation of the Mouse Developing Hypothalamus through In utero Electroporation
11:48

Genetic Manipulation of the Mouse Developing Hypothalamus through In utero Electroporation

Published on: July 24, 2013

In vitro Electroporation of the Lower Rhombic Lip of Midgestation Mouse Embryos
07:53

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Published on: August 3, 2012

  • Gene regulatory network analysis and comparative genomics.

    • Main Results:

    • TCDD-induced gene expression changes in the developing telencephalon are primarily AhR-dependent.
    • No significant changes were observed in AhR-/- mice exposed to TCDD.
    • Differentiation of ventral telencephalon GABAergic neurons is compromised in TCDD-exposed and AhR-/- mice.
    • Sox11 may be directly regulated by AhR.

    Conclusions:

    • AhR plays a critical role in normal telencephalon development.
    • TCDD exposure perturbs AhR signaling, leading to neurodevelopmental toxicity.
    • This study provides a mechanistic framework for understanding dioxin-like chemical neurotoxicity.